Novel homozygous mutations in PATL2 lead to female infertility with oocyte maturation arrest
نویسندگان
چکیده
منابع مشابه
Failure of oocyte maturation: possible mechanisms for oocyte maturation arrest.
For human IVF, the patient's ovaries are hormonally stimulated to ensure the collection of fully matured oocytes that are at the metaphase II stage. Only these oocytes can be successfully fertilized either when mixed with sperm or after ICSI. Nevertheless, in some cases immature or maturing oocytes are recovered from follicles. Surprisingly, sometimes these oocytes do not complete maturation wh...
متن کاملOOCYTE MATURATION DEFECT Oocyte Maturation Failure, Oocyte Defect Syndrome, Bad Eggs Syndrome, Meiotic Arrest, Oocyte Arrest, Maturation Arrest Of Human Oocytes
Oocyte maturation arrest is a complex problem not clearly understood; only few cases showing a complete oocyte maturation failure has been reported previously, still the exact incidence remains unknown. Failure to resume meiosis (a specialized type of cell division that reduces the chromosome number by half) in vivo may arise at one of the following three levels: absent or incomplete luteinizin...
متن کاملOOCYTE MATURATION DEFECT Oocyte Maturation Failure, Oocyte Defect Syndrome, Bad Eggs Syndrome, Meiotic Arrest, Oocyte Arrest, Maturation Arrest Of Human Oocytes
Oocyte maturation arrest is a complex problem not clearly understood; only few cases showing a complete oocyte maturation failure has been reported previously, still the exact incidence remains unknown. Failure to resume meiosis (a specialized type of cell division that reduces the chromosome number by half) in vivo may arise at one of the following three levels: absent or incomplete luteinizin...
متن کاملP-206: Mov10l1 Gene Polymorphisms Are Probably Associated to Male Infertility in Azoospermic Men with Complete Maturation Arrest
Background: Thousands of genes are involved in spermatogenesis. Alterations in any of these genes could lead to male infertility. Moloney leukemia virus 10-Like 1 (Mov10l1) gene is one of the genes that are expressed specifically in germ cells. Genetic disruption of this gene in mouse stops spermatogenesis during Meiosis I and causes azoospermia. Materials and Methods: In this study, the geneti...
متن کاملTransplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility
Ten to 15% of couples are infertile, with the most common causes being linked to the production of few or no oocytes or sperm. Yet, our understanding of human germ cell development is poor, at least in part due to the inaccessibility of early stages to genetic and developmental studies. Embryonic stem cells (ESCs) provide an in vitro system to study oocyte development and potentially treat fema...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Assisted Reproduction and Genetics
سال: 2020
ISSN: 1058-0468,1573-7330
DOI: 10.1007/s10815-020-01698-6